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Home > Products >  Antitussive Drug Pharmaceutical Raw Materials CAS 58-33-3

Antitussive Drug Pharmaceutical Raw Materials CAS 58-33-3 CAS NO.58-33-3

  • Product Details

Keywords

  • Promethazine Hydrochlorine
  • 58-33-3
  • Pharmaceutical Raw Materials

Quick Details

  • ProName: Antitussive Drug Pharmaceutical Raw Ma...
  • CasNo: 58-33-3
  • Molecular Formula: C17H21ClN2S
  • Appearance: white powder
  • Application: for research
  • DeliveryTime: product will be sent out with in 24 ho...
  • PackAge: according to the customers requriement...
  • Port: shanghai, shenzhen,hongkong
  • ProductionCapacity: 1 Metric Ton/Week
  • Purity: 99.9%
  • LimitNum: 1 Gram
  • Moisture Content: 0.005%
  • Impurity: 0.005%

Superiority

Price,company and service advantage:
 
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recent effective packing ways
 
4. Specials are possible when client's order is big enough, including the discount policy;
 
5. Our company promise to deliver clients' package to his hands safely, or we'll cover the total loss and reship in time;
 
6. We can help our regular clients to suggest some vials factories which produce different size vials(2ml, 5ml, 7ml, 10ml, 20ml...), hoping can bring you convenience if you need these vials, too.
 
7. Return policy: we promise we will return your money if our product don't have effect.

Details

 

 

Antitussive Drug Pharmaceutical Raw Materials Promethazine

 

Hydrochlorine

 

 

Quack Detail for Promethazine hydrochloride

Product Name Promethazine hydrochloride
Synonyms phenothiazine hydrochloride;Promethazine Hcl
CAS 58-33-3
MF C17H21ClN2S
MW 320.88
EINECS 200-375-2
Purity 99%
Appearance White Solid
Grade Pharma Grade
Usage For the treatment of allergic disorders, and nausea/vomiting.
Packing For the treatment of allergic disorders, and nausea/vomiting.
Storage Store in cool and dry area and keep away from direct sunlight.


Promethazine hydrochloride is a phenothiazine used to treat or prevent nausea and vomiting caused by anesthesia or surgery, certain types of allergic reactions, pain caused by surgery or childbirth, and to sedate patients before surgery or medical procedures. Promethazine injection is usually given when a person cannot take the medication orally (by mouth). Promethazine hydrochloride is available in generic form.

Promethazine hydrochloride suppositories (Brand Names: Phenadoz, Promethegan) is a phenothiazine that works by changing the actions of chemicals in your brain, and also acts as an antihistamine, used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. Promethazine hydrochloride suppositories is also used to prevent motion sickness, treat nausea and vomiting or pain after surgery, and as a sedative or sleep aid. Promethazine hydrochloride suppositories are available in generic form. Common side effects of promethazine hydrochloride suppositories include dizziness, drowsiness, sleepiness, restlessness, blurred vision, dry mouth, stuffy nose, ringing in the ears, weight gain, swelling in hands or feet, impotence, trouble having an orgasm, or constipation.

Promethazine hydrochloride COA

Product name promethazine hydrochloride
CAS No. 58-33-3 Outer Packing 25KG/DRUM
Production date APRIL 2016 Shelf life MARCH 2021
Standard adopted IP
Items of analysis Specification Results
description a white or faintly yellowish,crystalline powder a white crystalline powder
solubility very soluble in water,freely soluble in chloroform and in ethanol(95%) very soluble in water,freely soluble in chloroform and in ethanol(95%)
A. IR absorption spectrum positions and relative sizes of the banks in the spectrum positions and relative sizes of the bands in the spectrum
B.by TLC It complies with the identification test for phenothiazines it complies with the identification test for phenothiazine
C.Test with nitric acid forms orange colored solution and organge-red precipitate complies with test for chlorides
pH(10% w/v solution) 4.0-5.0 4.31
isopromethazine not more than 1.0% less than 1.0%
other impurity not more than 0.5% less than 0.5%
sulphated ash not more than 0.5% 0.20%
loss on drying at 105ºC not more than 0.5% 0.20%
assay 98.5-101%(on anhydrous basis) 100.0%
Conclusion Qualified
Product Name Promethazine hydrochloride
CAS 58-33-3
MF C17H21ClN2S
MW 320.88
EINECS 200-375-2
Purity 99%
Appearance White crystalline powder
HS Code 4010320000
Categories Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals ;Sulfur & Selenium Compounds;Histamine receptor;API;COLACE;Inhibitors
Synonyms 10-(2-dimethylamino-1-propyl)phenothiazine hydrochloride;PROMETHAZINE HCL;PROMETHAZINE HYDROCHLORIDE;PHENERGAN;10-(2-(dimethylamino)propyl)phenothiazinemonohydrochloride;10-(2-(dimethylamino)propyl)-phenothiazinmonohydrochloride;10-(2-dimethylaminopropyl)phenothiazinehydrochloride;10-(3-dimethylaminoisopropyl)phenothiazinehydrochloride



What is Promethazine hydrochloride

Promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family. The drug has strong sedative and weak antipsychotic effects. It also reduces motion sickness and has antiemetic and anticholinergic properties (via its action on the dopamine receptor D2). In some countries it is prescribed for insomnia when benzodiazepines are contraindicated. It is available in many countries under many brand names. Promethazine was developed in the mid 1940s when a team of scientists from Rhône-Poulenc laboratories were able to synthesize it from phenothiazine and a diamine side chain of diphenhydramine

Promethazine hydrochloride occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. It is soluble in water and freely soluble in alcohol.
Each tablet, for oral administration, contains 25 mg or 50 mg of promethazine hydrochloride. In addition each tablet contains the following inactive ingredients: dibasic calcium phosphate, magnesium stearate, microcrystalline cellulose, sodium starch glycolate and stearic acid.

Promethazine Hydrochloride Tablets USP, 50 mg also contain anhydrous lactose.


Usage:

1)Antihistaminic, antiemetic, CNS depressant.

2.For the treatment of allergic disorders, and nausea/vomiting.

3)With aminophylline in the treatment of asthma.

4)For the treatment of allergic disorders, and nausea/vomiting.

5)Dubbed hibernation and injection for artificial hibernation.

 

Promethazine hydrochloride COA:

Test Items Specification Test Results
Description White crystalline powder White crystalline powder
Identification IR , UV conform Conform
Loss on drying ≤0.5ml 0.21ml
Residue on ignition Not more than 0.2% 0.06ml
Iron Not more than 0.005% 0.0018%
Heavy metals Not more than 0.001% 0.0006%
Related substances Total: Not more than 1.0%
Individual: Not more than 0.5%
0.32%
0.14%
E-isomer Not more than 0.3% 0.19%
Organic volatile impurities Conforms Conforms
Assay 99.0~101.0% 99.51%
Conclusion Conform with USP30

 

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